Objective: To investigate the use of antiepileptic drugs in children with epilepsy

and to provide reference for clinical medication. Methods: The clinical data of 341 children who were admitted to the outpatient clinic of pediatric epilepsy specialty in two hospitals from February 2018 to August 2018 were reviewed

and the drug regimen selection and seizure control rate were statistically analyzed. Results: In 341 epilepsy patients investigated

the ratio of male to female was 1.04:1. The age of the patients ranged from 9 months old to 19 years old

and the median age was 6.75 years

and 32.55% of the patients were aged from 1 to 3 years. The treatment rates of single drug

double drug

three or more antiepileptic drugs were respectively 47.5%

29.6% and 22.9%. The overall seizure control rate of 341 patients above Grade II was 84.45% after treatment with antiepileptic drugs

. The control rates were 94.45%

69.63% and 45.56% in single drug treatment

double drug treatment and three or more combination treatment. The top three drugs used in single drug therapy were levetiracetam (LEV)

phenobarbital (PB) and carbamazepine (CBZ)

and the top three drugs used in multidrug therapy were LEV

VPA and TPM. Conclusion: The incidence of epilepsy in children is the most in infancy; Drug therapy was mainly single drug therapy

followed by dual drug combination therapy. LEV

Phenobarbital

CBZ

LEV

VPA and TPM are all first-line drugs for drug therapy

with high frequency of use. The most common two-drug combination regimens are LEV with VPA

LEV with TPM

or LEV with CZP.